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The Y-Maze test assessed spontaneous alternation, an indicator of working memory, as it measures the tendency of mice to explore novel arms of the maze rather than revisitations

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For example, referral to psychiatrists may be helpful since ME/CFS seems to coexist with anxiety disorders, symptoms of ME/CFS overlap with Major Depressive Disorder (MDD), and patients with severe ME/CFS may also be at risk of developing secondary MDD (36, 532)